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High-throughput droplet-based analysis of influenza A virus genetic reassortment by single-virus RNA sequencing

2 Feb 2023

Abstract excerpt

The segmented RNA genome of influenza A viruses (IAVs) enables viral evolution through genetic reassortment after multiple IAVs coinfect the same cell, leading to viruses harboring combinations of eight genomic segments from distinct parental viruses. Existing data indicate that reassortant genotypes are not equiprobable; however, the low throughput of available virology techniques does not allow quantitative...

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PMID: 36730204
DOI: 10.1073/pnas.2211098120

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