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A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects

21 Jul 2014

Abstract excerpt

The switch to a modern lifestyle in recent decades has coincided with a rapid increase in prevalence of obesity and other diseases. These shifts in prevalence could be explained by the release of genetic susceptibility for disease in the form of gene-by-environment (GxE) interactions. Yet, the detection of interaction effects requires large sample sizes, little replication has been reported, and a few studies...

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PMID: 25101110
DOI: 10.3389/fgene.2014.00225

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