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Article

Molecular mechanisms of thioridazine resistance in Staphylococcus aureus.

PloS one - 1 Jan 2018

Wassmann Claes Søndergaard, Lund Lars Christian, Thorsing Mette, Lauritzen Sabrina Prehn, Kolmos Hans Jørn, Kallipolitis Birgitte Haahr, Klitgaard Janne Kudsk

Abstract excerpt

Staphylococcus aureus has developed resistance towards the most commonly used anti-staphylococcal antibiotics. Therefore, there is an urgent need to find new treatment opportunities. A new approach relies on the use of helper compounds, which are able to potentiate the effect of antibiotics. A well-studied helper compound is thioridazine, which potentiates the effect of the β-lactam antibiotic dicloxacillin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30089175
DOI: 10.1371/journal.pone.0201767
PMCID: PMC6082566

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