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Article

Exposure of Methicillin-Resistant Staphylococcus aureus to Low Levels of the Antibacterial THAM-3ΦG Generates a Small Colony Drug-Resistant Phenotype.

Scientific reports - 29 Jun 2018

Weaver Alan J, Peters Tami R, Tripet Brian, Van Vuren Abigail, Rakesh, Lee Richard E, Copié Valérie, Teintze Martin

Abstract excerpt

This study investigated resistance against trishexylaminomelamine trisphenylguanide (THAM-3ΦG), a novel antibacterial compound with selective microbicidal activity against Staphylococcus aureus. Resistance development was examined by culturing methicillin resistant S. aureus (MRSA) with sub-lethal doses of THAM-3ΦG. This quickly resulted in the formation of normal (WT) and small colonies (SC) of S. aureus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29959441
DOI: 10.1038/s41598-018-28283-3
PMCID: PMC6026174

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