Article
Staphylococcal phenotypes induced by naturally occurring and synthetic membrane-interactive polyphenolic β-lactam resistance modifiers.
PloS one - 1 Jan 2014
Palacios Lucia, Rosado Helena, Micol Vicente, Rosato Adriana E, Bernal Patricia, Arroyo Raquel, Grounds Helen, Anderson James C, Stabler Richard A, Taylor Peter W
Abstract excerpt
Galloyl catechins, in particular (-)-epicatechin gallate (ECg), have the capacity to abrogate β-lactam resistance in methicillin-resistant strains of Staphylococcus aureus (MRSA); they also prevent biofilm formation, reduce the secretion of a large proportion of the exoproteome and induce profound changes to cell morphology. Current evidence suggests that these reversible phenotypic traits result from their...
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