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Article

Thioridazine as Chemotherapy for Mycobacterium avium Complex Diseases.

Antimicrobial agents and chemotherapy - 1 Aug 2016

Deshpande Devyani, Srivastava Shashikant, Musuka Sandirai, Gumbo Tawanda

Abstract excerpt

Mycobacterium avium-intracellulare complex (MAC) causes an intractable intracellular infection that presents as chronic pulmonary disease. Currently, therapy consists of ethambutol and macrolides and takes several years to complete. The neuroleptic phenothiazine thioridazine kills mycobacteria by inhibiting the electron transport chain. In several experiments with bacterial populations of up to 10(12) CFU/ml, we...

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Identifiers

PMID: 27216055
DOI: 10.1128/AAC.02985-15
PMCID: PMC4958214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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