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Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients

7 Aug 2018

Abstract excerpt

BACKGROUND: To deliver efficacious personalised cancer treatment, it is essential to characterise the cellular metabolism as well as the genetic stability of individual tumours. In this study, we describe a new axis between DNA repair and detoxification of aldehyde derivatives with important implications for patient prognosis and treatment. METHODS: Western blot and qPCR analyses were performed in relevant...

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PMID: 30088263
DOI: 10.1007/s13402-018-0390-8

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