Article
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.
Journal of molecular biology - 9 May 2008
Clark Kristopher, Middelbeek Jeroen, Lasonder Edwin, Dulyaninova Natalya G, Morrice Nick A, Ryazanov Alexey G, Bresnick Anne R, Figdor Carl G, van Leeuwen Frank N
Abstract excerpt
Deregulation of myosin II-based contractility contributes to the pathogenesis of human diseases, such as cancer, which underscores the necessity for tight spatial and temporal control of myosin II activity. Recently, we demonstrated that activation of the mammalian alpha-kinase TRPM7 inhibits myosin II-based contractility in a Ca(2+)- and kinase-dependent manner. However, the molecular mechanism is poorly...
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