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Article

Central precocious puberty: From genetics to treatment.

Best practice & research. Clinical endocrinology & metabolism - 1 Aug 2018

Aguirre Rebecca Schneider, Eugster Erica A

Abstract excerpt

Central precocious puberty (CPP) results from early activation of the hypothalamic - pituitary -gonadal (HPG) axis and follows the same sequence as normal puberty. While many factors involved in pubertal initiation remain poorly understood, the kisspeptin system is known to play a key role. Currently, mutations in the kisspeptin system, MKRN3, and DLK1 have been identified in sporadic and familial cases of CPP....

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Source

Identifiers

PMID: 30086862
DOI: 10.1016/j.beem.2018.05.008

Genes

DLK1
MKRN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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