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Article

Precocious Puberty: Growth and Genetics

1 Jan 2005

Abstract excerpt

The precise neuroendocrine mechanisms underlying activation of hypothalamic-pituitary-gonadal (HPG) axis maturation are elusive. The wide age range of pubertal onset among normal individuals throughout the world may suggest that both genetic and environmental factors modulate the timing of puberty. Early activation of the HPG axis, termed central precocious puberty (CPP), causes psychosocial difficulties and may...

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PMID: 16286772
DOI: 10.1159/000087760

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