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Targeting cancer stem cells and their niche: perspectives for future therapeutic targets and strategies

3 Aug 2018

Abstract excerpt

A small subpopulation of cells within the bulk of tumors share features with somatic stem cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to conventional therapy. These cells have been referred to as cancer stem cells (CSCs). Recent reports support the central importance of a cancer stem cell-like niche that appears to help foster the generation and maintenance of...

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PMID: 30081228
DOI: 10.1016/j.semcancer.2018.08.002

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