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Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection.

Cell systems - 26 Sept 2018

Patrick Kristin L, Wojcechowskyj Jason A, Bell Samantha L, Riba Morgan N, Jing Tao, Talmage Sara, Xu Pengbiao, Cabello Ana L, Xu Jiewei, Shales Michael, Jimenez-Morales David, Ficht Thomas A, de Figueiredo Paul, Samuel James E, Li Pingwei, Krogan Nevan J, Watson Robert O

Abstract excerpt

Intracellular bacterial pathogens secrete a repertoire of effector proteins into host cells that are required to hijack cellular pathways and cause disease. Despite decades of research, the molecular functions of most bacterial effectors remain unclear. To address this gap, we generated quantitative genetic interaction profiles between 36 validated and putative effectors from three evolutionarily divergent human...

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Identifiers

PMID: 30077634
DOI: 10.1016/j.cels.2018.06.010
PMCID: PMC6160342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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