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Article

Point mutation A394E in the central intrinsic disordered region of Rna14 leads to chromosomal instability in fission yeast.

International journal of biological macromolecules - 1 Nov 2018

Sonkar Amit, Lyngdoh Denzelle Lee, Shukla Rohit, Shukla Harish, Tripathi Timir, Ahmed Shakil

Abstract excerpt

Accurate chromosomal segregation is crucial for the maintenance of genomic integrity. Rna14 is a major component of the yeast pre-mRNA 3'-end processing factor, the cleavage factor IA complex, and is involved in cleavage and polyadenylation of mRNA in the nucleus. Rna14 is also essential for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe. In the present study, we report that a...

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PMID: 30076928
DOI: 10.1016/j.ijbiomac.2018.07.193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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