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Article

Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011

Hong Kuk-Ki, Vongsangnak Wanwipa, Vemuri Goutham N, Nielsen Jens

Abstract excerpt

Identification of the underlying molecular mechanisms for a derived phenotype by adaptive evolution is difficult. Here, we performed a systems-level inquiry into the metabolic changes occurring in the yeast Saccharomyces cerevisiae as a result of its adaptive evolution to increase its specific growth rate on galactose and related these changes to the acquired phenotypic properties. Three evolved mutants (62A,...

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Identifiers

PMID: 21715660
DOI: 10.1073/pnas.1103219108
PMCID: PMC3141923

Genes

PGM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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