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Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids

27 Jul 2018

Abstract excerpt

Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and disease. However, hPSC-derived hIOs still require in vivo maturation to fully recapitulate adult intestine, with the mechanism of maturation remaining elusive. Here, we show that the...

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PMID: 30072687
DOI: 10.1038/s41467-018-05450-8

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