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Article

miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4.

Molecular cancer research : MCR - 1 Dec 2018

Prossomariti Anna, Piazzi Giulia, D'Angelo Leonarda, Miccoli Sara, Turchetti Daniela, Alquati Chiara, Montagna Claudio, Bazzoli Franco, Ricciardiello Luigi

Abstract excerpt

Adenomatous Polyposis Coli (APC) gene mutations are responsible for the onset of familial adenomatous polyposis (FAP) and sporadic colorectal cancer and have been associated with miRNAs dysregulation. The capacity of miR-155, a cancer-related miRNA, to target components of the WNT/β-CATENIN pathway suggests that APC gene mutations, controlling miRNAs expression, may critically regulate WNT/β-CATENIN signaling. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30072583
DOI: 10.1158/1541-7786.MCR-18-0115

Genes

APC
FAP
AXIN1
TCF4
AXIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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