The clinical importance of CD4+ CD7- in human diseases.

doi:10.1002/jcp.27099

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Article

The clinical importance of CD4+ CD7- in human diseases.

Journal of cellular physiology - 1 Feb 2019

Haftcheshmeh Saeed Mohammadian, Tajbakhsh Amir, Kazemi Mohaddese, Esmaeili Seyed-Alireza, Mardani Fatemeh, Fazeli Mostafa, Sahebkar Amirhossein

Abstract excerpt

The CD7 antigen is a member of the immunoglobulin superfamily that expresses on the surface of all thymocytes, a majority of mature T cells, and also natural killer cells. Interestingly, under physiological and different pathological conditions, the loss of CD7 antigen occurred in the subset of CD4+ memory T cells. Various functions have been proposed for CD7, including its role in the activation and...

Topics

Animals
Antigens, CD7
Apoptosis
CD4-Positive T-Lymphocytes
Humans
Inflammation
Lymphocyte Activation
Lymphocytes, Tumor-Infiltrating
Neoplasms
Phenotype
Signal Transduction
Tumor Escape

Source

Open in PubMed

Identifiers

PMID: 30067877
DOI: 10.1002/jcp.27099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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