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Article

Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.

PloS one - 1 Jan 2018

Wang Ruey-Yun, Chen Hsiu-Ju, Huang Chieh-Liang, Wang Jiun-Yi, Lee Tsui-Er, Lee Hsiang-Yen, Hung Chin-Chuan

Abstract excerpt

Opioid addiction is a major public health issue worldwide. Methadone maintenance treatment (MMT) is used to detoxify users of illicit opiates, but drug relapse is common and associated with poor quality of life (QoL). This study investigated the associations between the GRIN3A, GRM6, and TPH2 genetic variants and QoL in the MMT population. A total of 319 participants were included in the study, and genotyping of...

Read the complete abstract on PubMed

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Share to TPH2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to Receptors, Glutamate

Share to Receptors, N-Methyl-D-Aspartate

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Source

Open in PubMed Open full text

Identifiers

PMID: 30059533
DOI: 10.1371/journal.pone.0201408
PMCID: PMC6066242

Genes

TPH2
GRM6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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