Article
ALDH5A1 variability in opioid dependent patients could influence response to methadone treatment.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Mar 2014
Fonseca Francina, Gratacòs Mònica, Escaramís Geòrgia, De Cid Rafael, Martín-Santos Rocío, Farré Magi, Estivill Xavier, Torrens Marta
Abstract excerpt
Methadone maintenance treatment is the most widely-used therapy in opioid dependence, but some patients relapse or drop out from treatment. We genotyped a genetic variant in the succinic semialdehyde dehydrogenase enzyme gene, ALDH5A1, and found that subjects carrying the T variant allele have a higher risk to be nonresponders to methadone treatment (OR=3.16; 95% CI [1.48-6.73], P=0.0024). This could be due to a...
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