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Article

Mitochondrial-Derived Peptides Exacerbate Senescence.

Rejuvenation research - 1 Aug 2018

Mendelsohn Andrew R, Larrick James W

Abstract excerpt

Mitochondrial-derived peptides (MDPs), encoded by mitochondrial DNA, play a cytoprotective role by helping preserve mitochondrial function and cell viability under stressful conditions. Humanin and its homologs and MOTS-c are two of several MDPs hypothesized to have antiaging activity based on correlative studies. For example, humanin plasma levels are inversely correlated with growth hormone and insulin-like...

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Identifiers

PMID: 30058454
DOI: 10.1089/rej.2018.2114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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