Article
The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes.
Molecular microbiology - 1 May 2009
Pan Yuanyuan, Liu Gang, Yang Haihua, Tian Yuqing, Tan Huarong
Abstract excerpt
The nikkomycin-producing strain Streptomyces ansochromogenes has a homologue (adpA-L) of the key pleiotropic Streptomyces regulatory gene adpA. Gene disruption and genetic complementation revealed that adpA-L was required for both nikkomycin biosynthesis and morphological differentiation. Transcriptional analysis suggested that the transcription of sanG, the specific activator gene for nikkomycin biosynthesis,...
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