Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

doi:10.1038/s41598-018-29434-2

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Article

Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

Scientific reports - 27 Jul 2018

Nikolakopoulou Polyxeni, Chatzigeorgiou Antonios, Kourtzelis Ioannis, Toutouna Louiza, Masjkur Jimmy, Arps-Forker Carina, Poser Steven W, Rozman Jan, Rathkolb Birgit, Aguilar-Pimentel Juan Antonio, Wolf Eckhard, Klingenspor Martin, Ollert Markus, Schmidt-Weber Carsten, Fuchs Helmut, Gailus-Durner Valerie, Hrabe de Angelis Martin, Tsata Vasiliki, Monasor Laura Sebastian, Troullinaki Maria, Witt Anke, Anastasiou Vivian, Chrousos George, Yi Chun-Xia, García-Cáceres Cristina, Tschöp Matthias H, Bornstein Stefan R, Androutsellis-Theotokis Andreas

Abstract excerpt

Diabetes mellitus is a group of disorders characterized by prolonged high levels of circulating blood glucose. Type 1 diabetes is caused by decreased insulin production in the pancreas whereas type 2 diabetes may develop due to obesity and lack of exercise; it begins with insulin resistance whereby cells fail to respond properly to insulin and it may also progress to decreased insulin levels. The brain is an...

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PMID: 30054579
DOI: 10.1038/s41598-018-29434-2
PMCID: PMC6063949

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