Article
The cardiac neural stem cell phenotype is compromised in streptozotocin-induced diabetic cardiomyopathy.
Journal of cellular physiology - 1 Aug 2009
El-Helou Viviane, Proulx Cindy, Béguin Pauline, Assimakopoulos John, Gosselin Hugues, Clement Robert, Villeneuve Louis, Huot-Marchand Julie-Emilie, Deblois Denis, Lajoie Claude, Calderone Angelino
Abstract excerpt
Neural stem cells were identified in the rat heart and during scar formation and healing participated in sympathetic fiber sprouting and angiogenesis. In the setting of diabetes, impaired wound healing represents a typical pathological feature. These findings provided the impetus to test the hypothesis that experimental diabetes adversely influenced the phenotype of cardiac neural stem cells. Streptozotocin...
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