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Article

Dynamic Changes of DNA Methylation and Lung Disease in Cystic Fibrosis: Lessons from a Monogenic Disease

27 Jul 2018

Abstract excerpt

AIM: To assess whether DNA methylation levels account for the noninherited phenotypic variations observed among cystic fibrosis (CF) patients. PATIENTS & METHODS: Using the 450 K BeadChip, we profiled DNA methylation in nasal epithelial cells collected from 32 CF patients and 16 controls. RESULTS: We detected substantial DNA methylation differences up to 55% (median β change 0.13; IQR: 0.15-0.11) between CF...

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PMID: 30052057
DOI: 10.2217/epi-2018-0005

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