Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common MLP (muscle LIM protein) variant is associated with cardiomyopathy.

Circulation research - 5 Mar 2010

Knöll Ralph, Kostin Sawa, Klede Stefanie, Savvatis Kostas, Klinge Lars, Stehle Ina, Gunkel Sylvia, Kötter Sebastian, Babicz Kamila, Sohns Melanie, Miocic Snjezana, Didié Michael, Knöll Gudrun, Zimmermann Wolfram Hubertus, Thelen Paul, Bickeböller Heike, Maier Lars S, Schaper Wolfgang, Schaper Jutta, Kraft Theresia, Tschöpe Carsten, Linke Wolfgang A, Chien Kenneth R

Abstract excerpt

RATIONALE: We previously discovered the human 10T-->C (Trp4Arg) missense mutation in exon 2 of the muscle LIM protein (MLP, CSRP3) gene. OBJECTIVE: We sought to study the effects of this single-nucleotide polymorphism in the in vivo situation. METHODS AND RESULTS: We now report the generation and detailed analysis of the corresponding Mlp(W4R/+) and Mlp(W4R/W4R) knock-in animals, which develop an age- and gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Myocardial Contraction
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connectin

Share to Fibrosis

Share to Gene Knock-In Techniques

Share to Heart Failure

Share to LIM Domain Proteins

Share to Ventricular Function, Left

Source

Identifiers

PMID: 20044516
DOI: 10.1161/CIRCRESAHA.109.206243

Genes

CSRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common MLP (muscle LIM protein) variant is associated with cardiomyopathy.PMID 20044516Read ↗

MLP (muscle LIM protein) as a stress sensor in the heartSemantic proximity Read ↗

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion.Semantic proximity Read ↗

Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiationSemantic proximity Read ↗

Muscle LIM protein plays both structural and functional roles in skeletal muscle.Semantic proximity Read ↗

Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP).Semantic proximity Read ↗

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathySemantic proximity Read ↗

Mutations in <i>CSRP3/MLP</i>, a Z-disc associated gene are functionally associated with dilated cardiomyopathy in Indian populationSemantic proximity Read ↗

Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.Semantic proximity Read ↗

The<i>Drosophila</i>muscle LIM protein, Mlp84B, is essential for cardiac functionSemantic proximity Read ↗

Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP).Semantic proximity Read ↗

Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.