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Article

Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.

Circulation - 18 Mar 2003

Geier Christian, Perrot Andreas, Ozcelik Cemil, Binner Priska, Counsell Damian, Hoffmann Katrin, Pilz Bernhard, Martiniak Yvonne, Gehmlich Katja, van der Ven Peter F M, Fürst Dieter O, Vornwald Arnold, von Hodenberg Eberhard, Nürnberg Peter, Scheffold Thomas, Dietz Rainer, Osterziel Karl Josef

Abstract excerpt

BACKGROUND: Muscle LIM protein (MLP) is an essential nuclear regulator of myogenic differentiation. Additionally, it may act as an integrator of protein assembly of the actin-based cytoskeleton. MLP-knockout mice develop a marked cardiac hypertrophy reaction and dilated cardiomyopathy (DCM). MLP is therefore a candidate gene for heritable forms of hypertrophic cardiomyopathy (HCM) and DCM in humans. METHODS AND...

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Source

Identifiers

PMID: 12642359
DOI: 10.1161/01.cir.0000056522.82563.5f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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