Article
Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy.
Circulation - 17 Oct 2017
Barefield David Y, Puckelwartz Megan J, Kim Ellis Y, Wilsbacher Lisa D, Vo Andy H, Waters Emily A, Earley Judy U, Hadhazy Michele, Dellefave-Castillo Lisa, Pesce Lorenzo L, McNally Elizabeth M
Abstract excerpt
BACKGROUND: Cardiomyopathy and arrhythmias are under significant genetic influence. Here, we studied a family with dilated cardiomyopathy and associated conduction system disease in whom prior clinical cardiac gene panel testing was unrevealing. METHODS: Whole-genome sequencing and induced pluripotent stem cells were used to examine a family with dilated cardiomyopathy and atrial and ventricular arrhythmias. We...
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