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Article

Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development

18 Jun 2018

Abstract excerpt

Abstract Over 50 million women are exposed to the risk of malaria during pregnancy every year. Malaria during pregnancy is a leading global cause of maternal morbidity and adverse pregnancy outcomes. Adhesion of Plasmodium falciparum -infected erythrocytes to placental chondroitin-4-sulfate (CSA) has been linked to the severe disease outcome of placental malaria. Accumulated evidence strongly supports VAR2CSA as...

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PMID: 30038803
DOI: 10.1038/s41541-018-0064-6

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Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine developmentPMID 30038803Read ↗

Multilaboratory Approach to Preclinical Evaluation of Vaccine Immunogens for Placental MalariaSemantic proximity Read ↗

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Induction of Adhesion-Inhibitory Antibodies against Placental<i>Plasmodium falciparum</i>Parasites by Using Single Domains of VAR2CSASemantic proximity Read ↗

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Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Semantic proximity Read ↗

Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSASemantic proximity Read ↗

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolatesSemantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.Semantic proximity Read ↗

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Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine.Semantic proximity Read ↗

Immunogenicity of Duffy Binding-Like Domains That Bind Chondroitin Sulfate A and Protection against Pregnancy-Associated MalariaSemantic proximity Read ↗

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