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Article

Multilaboratory Approach to Preclinical Evaluation of Vaccine Immunogens for Placental Malaria

4 Dec 2012

Abstract excerpt

Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a...

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PMID: 23208604
DOI: 10.1128/iai.01106-12

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Related research

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Multilaboratory Approach to Preclinical Evaluation of Vaccine Immunogens for Placental MalariaPMID 23208604Read ↗

Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine developmentSemantic proximity Read ↗

Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSASemantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

Induction of Adhesion-Inhibitory Antibodies against Placental<i>Plasmodium falciparum</i>Parasites by Using Single Domains of VAR2CSASemantic proximity Read ↗

Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteinsSemantic proximity Read ↗

Effects of Sex, Parity, and Sequence Variation on Seroreactivity to Candidate Pregnancy Malaria Vaccine AntigensSemantic proximity Read ↗

Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Semantic proximity Read ↗

Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.Semantic proximity Read ↗

Immunogenicity of Duffy Binding-Like Domains That Bind Chondroitin Sulfate A and Protection against Pregnancy-Associated MalariaSemantic proximity Read ↗

<i>Aotus nancymaae</i> model predicts human immune response to the placental malaria vaccine candidate VAR2CSASemantic proximity Read ↗

Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strainsSemantic proximity Read ↗

VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to<i>Plasmodium falciparum</i>Placental MalariaSemantic proximity Read ↗

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