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On the origin of the human germline

23 Jul 2018

Abstract excerpt

ABSTRACT In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) has been less clear and has been difficult to study because of the technical and ethical constraints that limit direct studies on human embryos. In recent years, however, in vitro simulation models using human pluripotent stem...

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Identifiers

PMID: 30037844
DOI: 10.1242/dev.150433

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