Article
Haemophilus parasuis α-2,3-sialyltransferase-mediated lipooligosaccharide sialylation contributes to bacterial pathogenicity.
Virulence - 1 Jan 2018
Wang Huan, Liu Lu, Cao Qi, Mao Weiting, Zhang Yage, Qu Xinyi, Cai Xuwang, Lv Yujin, Chen Huanchun, Xu Xiaojuan, Wang Xiangru
Abstract excerpt
Bacterial lipooligosaccharide (LOS) is an important virulence-associated factor, and its sialylation largely confers its ability to mediate cell adhesion, invasion, inflammation, and immune evasion. Here, we investigated the function of the Haemophilus parasuis α-2,3-sialyltransferase gene, lsgB, which determines the terminal sialylation of LOS, by generating a lsgB deletion mutant as well as a complementation...
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