Article
Functional characterization of an isogenic meningococcal alpha-2,3-sialyltransferase mutant: the role of lipooligosaccharide sialylation for serum resistance in serogroup B meningococci.
Medical microbiology and immunology - 1 Oct 1997
Vogel U, Claus H, Heinze G, Frosch M
Abstract excerpt
The neisserial alpha-2,3-sialyltransferase, which is encoded by the lst gene, terminally links sialic acid to the lacto-N-neotetraose residue of neisserial lipooligosaccharide (LOS). We used the recently published nucleotide sequence of the neisserial lst gene to construct an isogenic serogroup B...
Topics
- Animals
- Blood Bactericidal Activity
- Carbohydrate Sequence
- Complement C3
- Disease Models, Animal
- Genes, Bacterial
- Humans
- Immunoglobulin M
- In Vitro Techniques
- Lipopolysaccharides
- Meningococcal Infections
- Molecular Sequence Data
- Mutation
- Neisseria meningitidis
- Phenotype
- Rats
- Serotyping
- Sialyltransferases