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Multiple roles for the cytoskeleton in ALS

14 Jun 2022

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by more than sixty genes identified through classic linkage analysis and new sequencing methods. Yet no clear mechanism of onset, cure, or effective treatment is known. Popular discourse classifies the proteins encoded from ALS-related genes into four disrupted processes: proteostasis, mitochondrial function and ROS, nucleic...

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PMID: 35714755
DOI: 10.1016/j.expneurol.2022.114143

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