Article
TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity.
Nature communications - 20 Jul 2018
Riquelme Paloma, Haarer Jan, Kammler Anja, Walter Lisa, Tomiuk Stefan, Ahrens Norbert, Wege Anja K, Goecze Ivan, Zecher Daniel, Banas Bernhard, Spang Rainer, Fändrich Fred, Lutz Manfred B, Sawitzki Birgit, Schlitt Hans J, Ochando Jordi, Geissler Edward K, Hutchinson James A
Abstract excerpt
Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4+ T cells to IL-10-producing, TIGIT+ FoxP3+-induced regulatory T cells that...
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