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Article

Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Jan 2018

Sutton P A, Jithesh P V, Jones R P, Evans J P, Vimalachandran D, Malik H Z, Park B K, Goldring C E, Palmer D H, Kitteringham N R

Abstract excerpt

BACKGROUND: Next generation sequencing technology has facilitated mapping of the colorectal cancer genotype and furthered our understanding of metastogenesis. The aim of this study was to investigate for conserved and different mutations in the exomes of synchronously resected primary colorectal tumour and liver metastases. This information could potentially be utilised to guide the treatment of advanced disease...

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Chemotherapy, Adjuvant
Colectomy
Combined Modality Therapy
DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

Neoplasm Metastasis

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PMID: 29174709
DOI: 10.1016/j.ejso.2017.10.211

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