Article
Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.
The Journal of biological chemistry - 8 May 2015
Curran Jerry, Musa Hassan, Kline Crystal F, Makara Michael A, Little Sean C, Higgins John D, Hund Thomas J, Band Hamid, Mohler Peter J
Abstract excerpt
Proper trafficking of membrane-bound ion channels and transporters is requisite for normal cardiac function. Endosome-based protein trafficking of membrane-bound ion channels and transporters in the heart is poorly understood, particularly in vivo. In fact, for select cardiac cell types such as atrial myocytes, virtually nothing is known regarding endosomal transport. We previously linked the C-terminal Eps15...
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