Article
Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis.
Asian journal of andrology - 1 Jan 2000
Dantsev Ilya S, Ivkin Evgeniy V, Tryakin Aleksey A, Godlevski Dmitriy N, Latyshev Oleg Yu, Rudenko Victoriya V, Mikhaylenko Dmitry S, Chernykh Vyacheslav B, Volodko Elena A, Okulov Aleksey B, Loran Oleg B, Nemtsova Marina V
Abstract excerpt
Testicular microlithiasis (TM) is one of the symptoms of testicular dysgenesis syndrome (TDS). TM is particularly interesting as an informative marker of testicular germ cell tumors (TGCTs). KIT ligand gene (KITLG), BCL2 antagonist/killer 1 (BAK1), and sprouty RTK signaling antagonist 4 (SPRY4) genes are associated with a high risk of TGCTs, whereas bone morphogenetic protein 7 gene (BMP7), transforming growth...
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