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Article

Deletion-based escape of CRISPR-Cas9 targeting in Lactobacillus gasseri.

Microbiology (Reading, England) - 1 Sept 2018

Stout Emily A, Sanozky-Dawes Rosemary, Goh Yong Jun, Crawley Alexandra B, Klaenhammer Todd R, Barrangou Rodolphe

Abstract excerpt

Lactobacillus gasseri is a human commensal which carries CRISPR-Cas, an adaptive immune system that protects the cell from invasive mobile genetic elements (MGEs). However, MGEs occasionally escape CRISPR targeting due to DNA mutations that occur in sequences involved in CRISPR interference. To better understand CRISPR escape processes, a plasmid interference assay was used to screen for mutants that escape...

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Share to Clustered Regularly Interspaced Short Palindromic Repeats
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interspersed Repetitive Sequences

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PMID: 30024364
DOI: 10.1099/mic.0.000689

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PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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