Article
Impact of ABCB1 genotype in Collies on the pharmacokinetics of R- and S-fexofenadine.
Journal of veterinary pharmacology and therapeutics - 1 Dec 2018
Myers Michael J, Martinez Marilyn, Li Fei, Howard Karyn, Yancy Haile F, Troutman Lisa, Sharkey Michele
Abstract excerpt
Thirty-two Collies were used to determine the impact of ABCB1 genotype and phenotype on the plasma pharmacokinetics of fexofenadine's (Fex) R- and S-enantiomers after bolus Fex administration, as human P-gp exhibits stereoselectivity. Each Collie's ABCB1 genotype and ivermectin (IVM) sensitivity (phenotype) was determined prior to study enrolment. Wild-type (WT) Collies had lower plasma concentrations of the...
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