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Article

Novel neuroendocrine role of γ-aminobutyric acid and gastrin-releasing peptide in the host response to influenza infection

23 Mar 2023

Abstract excerpt

Gastrin-releasing peptide (GRP), an evolutionarily conserved neuropeptide, significantly contributes to influenza-induced lethality and inflammation in rodent models. Because GRP is produced by pulmonary neuroendocrine cells (PNECs) in response to γ-aminobutyric acid (GABA), we hypothesized that influenza infection promotes GABA release from PNECs that activate GABA B receptors on PNECs to secrete GRP. Oxidative...

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PMID: 36965691
DOI: 10.1016/j.mucimm.2023.03.004

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