Article
Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates.
The Journal of clinical investigation - 1 Oct 2018
Gu Xiaorong, Ebrahem Quteba, Mahfouz Reda Z, Hasipek Metis, Enane Francis, Radivoyevitch Tomas, Rapin Nicolas, Przychodzen Bartlomiej, Hu Zhenbo, Balusu Ramesh, Cotta Claudiu V, Wald David, Argueta Christian, Landesman Yosef, Martelli Maria Paola, Falini Brunangelo, Carraway Hetty, Porse Bo T, Maciejewski Jaroslaw, Jha Babal K, Saunthararajah Yogen
Abstract excerpt
Nucleophosmin (NPM1) is among the most frequently mutated genes in acute myeloid leukemia (AML). It is not known, however, how the resulting oncoprotein mutant NPM1 is leukemogenic. To reveal the cellular machinery in which NPM1 participates in myeloid cells, we analyzed the endogenous NPM1 protein interactome by mass spectrometry and discovered abundant amounts of the master transcription factor driver of...
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