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Article

CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye.

Molecular vision - 1 Jan 2015

Wang Jay Ching Chieh, Cao Sijia, Wang Aikun, To Eleanor, Law Geoffrey, Gao Jiangyuan, Zhang Dean, Cui Jing Z, Matsubara Joanne A

Abstract excerpt

PURPOSE: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people 50 years of age or older in developed countries. The homozygous CC genotype in the complement factor H (CFH) Y402H single nucleotide polymorphism (SNP; rs1061170) is widely recognized as a ris...

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Source

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Identifiers

PMID: 25814824
PMCID: PMC4360164

Genes

CFH
RPE
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25814824-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye.PMID 25814824Read ↗

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