Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2018

Tang Wei, Wallace Tiffany A, Yi Ming, Magi-Galluzzi Cristina, Dorsey Tiffany H, Onabajo Olusegun O, Obajemu Adeola, Jordan Symone V, Loffredo Christopher A, Stephens Robert M, Silverman Robert H, Stark George R, Klein Eric A, Prokunina-Olsson Ludmila, Ambs Stefan

Abstract excerpt

Purpose: Men of African ancestry experience an excessive prostate cancer mortality that could be related to an aggressive tumor biology. We previously described an immune-inflammation signature in prostate tumors of African-American (AA) patients. Here, we further deconstructed this signature and investigated its relationships with tumor biology, survival, and a common germline variant in the IFNλ4 (IFNL4)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Germ-Line Mutation
Share to Interferons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukins

Share to Prostatic Neoplasms

Share to Recurrence

Share to Sequence Deletion

Share to Transcriptome

Share to Tryptophan

Source

Open in PubMed Open full text

Identifiers

PMID: 30012562
DOI: 10.1158/1078-0432.CCR-18-1060
PMCID: PMC6214748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer.PMID 30012562Read ↗

Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differencesSemantic proximity Read ↗

Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genesSemantic proximity Read ↗

Human herpesvirus 8 infection is associated with prostate cancer among IFNL4-ΔG carriers.Semantic proximity Read ↗

Racial variation in the advanced prostate cancer genomeSemantic proximity Read ↗

Prioritization of prostate cancer to immune checkpoint therapy by ranking tumors along IFN-γ axis and identification of immune resistance mechanismsSemantic proximity Read ↗

FOXA1 overexpression suppresses interferon signaling and immune response in cancerSemantic proximity Read ↗

Interferon-lambda (IFNL) germline variations and their significance for HCC and PDAC progression: an analysis of The Cancer Genome Atlas (TCGA) data.Semantic proximity Read ↗

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineagesSemantic proximity Read ↗

Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancerSemantic proximity Read ↗

Inflammation, infection, and prostate cancer.Semantic proximity Read ↗

WITHDRAWN: GATA2 promotes castration-resistant prostate cancer development by suppressing IFN-β axis-mediated antitumor immunitySemantic proximity Read ↗

Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.