Article
Conserved Active-Site Residues Associated with OAS Enzyme Activity and Ubiquitin-Like Domains Are Not Required for the Antiviral Activity of goOASL Protein against Avian Tembusu Virus.
Viruses - 15 Jul 2018
Chen Shun, Yang Chao, Zhang Jinyue, Wu Zhen, Wang Mingshu, Jia Renyong, Zhu Dekang, Liu Mafeng, Yang Qiao, Wu Ying, Zhao Xinxin, Zhang Shaqiu, Liu Yunya, Zhang Ling, Yu Yanling, You Yu, Cheng Anchun
Abstract excerpt
Interferon (IFN)-induced 2'-5'-oligoadenylate synthetase (OAS) proteins exhibit an extensive and efficient antiviral effect against flavivirus infection in mammals and birds. Only the 2'-5'-oligoadenylate synthetase-like (OASL) gene has been identified thus far in birds, except for ostrich, which has both OAS1 and OASL genes. In this study, we first investigated the antiviral activity of goose OASL (goOASL)...
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