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Porcine 2′, 5′‐oligoadenylate synthetases inhibit Japanese encephalitis virus replication in vitro

6 Oct 2015

Abstract excerpt

The 2', 5'-oligoadenylate synthetases (OAS) are antiviral proteins and several isoforms have been identified as flavivirus-resistance biomarkers in human and mouse. The expression kinetics and antiviral functions of porcine OAS family (OAS1, OAS2, and OASL) in PK-15 cells following infection by Japanese encephalitis virus (JEV) were evaluated in the present study. The endogenous expression of the three OAS genes...

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PMID: 26437676
DOI: 10.1002/jmv.24397

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