Article
Selected Phytoestrogens Distinguish Roles of ERα Transactivation and Ligand Binding for Anti-Inflammatory Activity.
Endocrinology - 1 Sept 2018
Liu Haixin, He Shuang, Wang Taiyi, Orang-Ojong Barnabas, Lu Qing, Zhang Zhongqun, Pan Lanlan, Chai Xin, Wu Honghua, Fan Guanwei, Zhang Peng, Feng Yuxin, Song Yun Seon, Gao Xuimei, Karas Richard H, Zhu Yan
Abstract excerpt
Estrogen receptor α (ERα) is a ligand-activated transcriptional activator that is also involved vascular inflammation and atherosclerosis. Whether different ligands may affect this activity has not been explored. We screened a panel of phytoestrogens for their role in ERα binding and transcriptional transcription, and correlated the findings to anti-inflammatory activities in vascular endothelial cells stably...
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