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Article

Selective Estrogen Receptor-β Agonists Repress Transcription of Proinflammatory Genes

1 Jan 2008

Abstract excerpt

In addition to their role in the development and function of the reproductive system, estrogens have significant anti-inflammatory properties. Although both estrogen receptors (ERs) can mediate anti-inflammatory actions, ERbeta is a more desirable therapeutic target because ERalpha mediates the proliferative effects of estrogens on the mammary gland and uterus. In fact, selective ERbeta agonists have beneficial...

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PMID: 18097065
DOI: 10.4049/jimmunol.180.1.630

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