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Article

Differential Ligand Binding Affinities of Human Estrogen Receptor-α Isoforms

30 Apr 2013

Abstract excerpt

Rapid non-genomic effects of 17β-estradiol are elicited by the activation of different estrogen receptor-α isoforms. Presence of surface binding sites for estrogen have been identified in cells transfected with full-length estrogen receptor-α66 (ER66) and the truncated isoforms, estrogen receptor-α46 (ER46) and estrogen receptor-α36 (ER36). However, the binding affinities of the membrane estrogen receptors (mERs)...

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PMID: 23646196
DOI: 10.1371/journal.pone.0063199

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