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Article

The BRG1/SOX9 axis is critical for acinar cell–derived pancreatic tumorigenesis

15 Jul 2018

Abstract excerpt

Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that BRG1 inhibits the formation of intraductal pancreatic mucinous neoplasm (IPMN) and that IPMN-derived PDA originated from ductal cells. However, the role of BRG1 in pancreatic intraepithelial neoplasia-derived (PanIN-derived) PDA that originated from acinar...

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PMID: 30010625
DOI: 10.1172/jci94287

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