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What is the evidence in humans that DNA methylation changes link events in utero and later life disease?

Clinical endocrinology - 1 Jun 2013

Reynolds Rebecca M, Jacobsen Greta H, Drake Amanda J

Abstract excerpt

Development in utero is now recognized as crucial to determining later life disease susceptibility. Whilst mechanisms are poorly understood, there has been considerable interest in the potential role of epigenetic processes in intra-uterine programming of disease. Epigenetic modifications include various mechanisms that influence chromatin structure and gene expression. Here, we review emerging data from human...

Topics

Adult
Biomarkers
Birth Weight
DNA Methylation
Epigenesis, Genetic
Female
Fetal Blood
Fetal Development
Genetic Predisposition to Disease
Humans
Infant, Newborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Obesity

Placentation

Pregnancy

Prenatal Exposure Delayed Effects

Source

Identifiers

PMID: 23374091
DOI: 10.1111/cen.12164

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